Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 7/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057462 | 0.97 | HTR3A (0.59) | HTR3AHRH3KCNH2KDM1ANPY1R | |
| SCHEMBL4060869 | 0.80 | HTR3A (0.60) | HTR3AHRH3KCNH2KDM1ANPY1R | |
| SCHEMBL4057147 | 0.79 | HRH3 (0.56) | HTR3AHRH3KCNH2NPY1RCHRM2 | |
| SCHEMBL4057615 | 0.77 | HRH3 (0.59) | HTR3AHRH3KCNH2NPY1RCHRM2 | |
| SCHEMBL1375434 | 0.76 | HTR3A (0.67) | HTR3AHRH3KCNH2 | |
| SCHEMBL4061241 | 0.76 | HRH3 (0.48) | HTR3AHRH3KCNH2NPY1RCHRM2 | |
| SCHEMBL4059456 | 0.76 | HRH3 (0.47) | HTR3AHRH3KCNH2KDM1ANPY1R | |
| SCHEMBL4057349 | 0.74 | HTR3A (0.58) | HTR3AHRH3KCNH2NPY1RHPGD | |
| SCHEMBL4055490 | 0.74 | HRH3 (0.56) | HTR3AHRH3KCNH2CHRM2SLC6A2 | |
| SCHEMBL1373478 | 0.73 | HTR3A (1.00) | HTR3AHRH3KCNH2CHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |