Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 13/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1373281 | 1.00 | HTR3A (0.70) | HTR3AHRH3ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL1375646 | 0.82 | HTR3A (1.00) | HTR3AHRH3KCNH2 | |
| SCHEMBL1372915 | 0.82 | HTR3A (1.00) | HTR3AHRH3KCNH2 | |
| SCHEMBL1373496 | 0.79 | HTR3A (0.56) | HTR3A | |
| SCHEMBL1375210 | 0.78 | HTR3A (1.00) | HTR3AHRH3KCNH2 | |
| SCHEMBL2114693 | 0.77 | HRH3 (0.61) | HTR3AHRH3ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL3617516 | 0.76 | HTR3A (0.72) | HTR3AHRH3CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL3610358 | 0.76 | HTR3A (0.71) | HTR3AHRH3ADORA2ACYP19A1KCNH2 | |
| SCHEMBL4059363 | 0.75 | HTR3A (0.59) | HTR3AHRH3KCNH2 | |
| SCHEMBL4057349 | 0.75 | HTR3A (0.58) | HTR3AHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |