Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NCF1 | P14598 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10020390 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL3089963 | 0.79 | CYP1A2 (0.48) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL20746476 | 0.79 | NCF1 (0.43) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL7461862 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL1261383 | 0.79 | ALDH1A1 (0.54) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL1115861 | 0.79 | ALDH1A1 (0.46) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL9009627 | 0.78 | NCF1 (0.50) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL1848409 | 0.76 | ALDH1A1 (0.59) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL4138519 | 0.76 | ALDH1A1 (0.51) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 | |
| SCHEMBL19190794 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HSD17B10NCF1CYP1A2NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |