Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 13/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MATK | P42679 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992192 | 0.92 | MAPK14 (0.45) | PRKCQCYP2C9CYP3A4CYP2D6DCLK1 | |
| SCHEMBL4063490 | 0.90 | PRKCQ (0.44) | PRKCQMAPK14 | |
| SCHEMBL4067180 | 0.85 | MAPK14 (0.49) | CYP2C9CYP2D6MAPK14PTGES | |
| SCHEMBL4067857 | 0.83 | MAPK14 (0.45) | PRKCQCYP3A4CSNK1DMAPK14 | |
| SCHEMBL4064671 | 0.81 | PRKCQ (0.45) | PRKCQCYP2C9CYP3A4CYP2D6DCLK1 | |
| SCHEMBL3989359 | 0.80 | MAPK14 (0.57) | CYP2C9MAPK14PTGES | |
| SCHEMBL3993152 | 0.79 | MAPK14 (0.45) | CYP2C9CYP2D6PRKACAMAPK14PTGES | |
| SCHEMBL3989284 | 0.78 | MAPK14 (0.43) | CYP2C9MAPK14PTGES | |
| SCHEMBL4061072 | 0.78 | MAPK14 (0.55) | CYP2C9CYP3A4CSNK1DMAPK14PTGES | |
| SCHEMBL3997933 | 0.74 | MAPK14 (0.51) | CSNK1DMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713805-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2009-06-10 | — | — | EP | disclosed |