⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16774611 | 0.83 | — | — | |
| SCHEMBL29366973 | 0.81 | — | — | |
| SCHEMBL31475175 | 0.79 | — | — | |
| SCHEMBL31220497 | 0.79 | — | — | |
| SCHEMBL23909580 | 0.78 | — | — | |
| SCHEMBL8824808 | 0.75 | — | — | |
| SCHEMBL28840575 | 0.74 | — | — | |
| SCHEMBL21799341 | 0.74 | ALOX15 (0.33) | — | |
| SCHEMBL1184894 | 0.69 | — | — | |
| SCHEMBL15564384 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737831-B1 | NEUROLOGICALLY-ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LTD (AU) | 2013-05-22 | — | — | EP | disclosed |
| US-8084459-B2 | 8-hydroxy-3H-quinazolin-4-(thi)one derivatives; ability to enter CNS, sequester transition metals Cu, Zn and Fe from various amiloid beta entities, reducing their toxicity; neurodegenerative disorders; Alzheimer's, Parkinson's, Cruetzfeldt-Jacob diseases, amyotrophic lateral sclerosis, cataract | PRANA BIOTECHNOLOGY LTD (AU) | 2011-12-27 | — | — | US | disclosed |
| EP-1737831-A4 | NEUROLOGICALLY-ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LTD (AU) | 2009-07-22 | — | — | EP | disclosed |
| US-20080119470-A1 | Neurologically-Active Compounds | XOMA TECHNOLOGY LTD. | 2008-05-22 | — | — | US | disclosed |
| EP-1737831-A1 | NEUROLOGICALLY-ACTIVE COMPOUNDS | Prana Biotechnology Limited (AU) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005095360-A1 | NEUROLOGICALLY-ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2005-10-13 | — | — | WO | disclosed |