Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GRM8 | O00222 | 1/20 | 0.53 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060811 | 0.89 | GRM8 (0.56) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL4067290 | 0.89 | GRM8 (0.53) | RAB9AMAPK1LMNAKMT2AMEN1 | |
| SCHEMBL4064115 | 0.86 | GRM8 (0.52) | RAB9ALMNAKMT2AMEN1NPC1 | |
| SCHEMBL4058614 | 0.83 | GRM8 (0.53) | LMNAGRM8GRM7GRM4 | |
| SCHEMBL4063387 | 0.83 | NPC1 (0.53) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL4069994 | 0.82 | NPC1 (0.54) | RAB9ALMNAKMT2AMEN1BRAF | |
| SCHEMBL4061697 | 0.82 | GRM8 (0.55) | LMNAGRM8GRM7GRM4 | |
| SCHEMBL4062244 | 0.82 | PNLIP (0.60) | RAB9AKMT2AMEN1NPC1CYP11B2 | |
| SCHEMBL4065181 | 0.81 | GRM4 (0.57) | KMT2AMEN1GRM8GRM7GRM4 | |
| SCHEMBL15093308 | 0.81 | MEN1 (0.60) | MAPK1LMNAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |