Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.51 |
| ▸ | CASP3 | P42574 | 3/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | PARG | Q86W56 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060811 | 0.89 | GRM8 (0.56) | NPC1RAB9AMEN1KMT2AGRM8 | |
| SCHEMBL4069994 | 0.86 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4064115 | 0.85 | GRM8 (0.52) | NPC1RAB9AMEN1KMT2AGRM8 | |
| SCHEMBL4062244 | 0.83 | PNLIP (0.60) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL4067290 | 0.83 | GRM8 (0.53) | NPC1RAB9AMEN1KMT2AGRM8 | |
| SCHEMBL4065169 | 0.83 | RAB9A (0.57) | NPC1RAB9AMEN1KMT2AGRM8 | |
| SCHEMBL4229637 | 0.82 | HTR2C (0.67) | HTR2C | |
| SCHEMBL4065181 | 0.82 | GRM4 (0.57) | MEN1KMT2AGRM8GRM7GRM4 | |
| SCHEMBL4058614 | 0.82 | GRM8 (0.53) | GRM8GRM7GRM4HTR2C | |
| SCHEMBL4240750 | 0.82 | PNLIP (0.56) | GRM8GRM7GRM4PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |