Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9782199 | 0.84 | MAPT (0.47) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL9671321 | 0.84 | MAPT (0.42) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL9672478 | 0.84 | MAPT (0.42) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL158378 | 0.84 | MAPT (0.42) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL14883426 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL23857484 | 0.75 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL27405623 | 0.75 | MAPT (0.45) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL907623 | 0.75 | MAPT (0.45) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL14058597 | 0.75 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL69190 | 0.73 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009033689-A1 | PIPERIDONE DERIVATIVES AND MEDICAL USES THEREOF | HEINRICH-PETTE-INSTITUT (DE) | 2009-03-19 | — | — | WO | disclosed |
| EP-2036556-A1 | Piperidone derivatives and medical uses thereof | Heinrich-Pette-Institut (DE) | 2009-03-18 | — | — | EP | disclosed |