Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 17/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065304 | 0.90 | SIGMAR1 (0.36) | SLC6A2SLC6A3KCNH2SLC6A4OPRK1 | |
| SCHEMBL4937965 | 0.87 | SLC6A2 (0.41) | SLC6A2SLC6A3KCNH2SLC6A4HTR2C | |
| SCHEMBL4937969 | 0.85 | SLC6A2 (0.40) | SLC6A2SLC6A3KCNH2SLC6A4OPRK1 | |
| SCHEMBL4060071 | 0.83 | SLC6A2 (0.46) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4055089 | 0.83 | SLC6A2 (0.46) | SLC6A2SLC6A3KCNH2SLC6A4SIGMAR1 | |
| SCHEMBL4056483 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4056104 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4055075 | 0.76 | SLC6A2 (0.43) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4061994 | 0.76 | SLC6A2 (0.43) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4937958 | 0.76 | SLC6A2 (0.46) | SLC6A2SLC6A3KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |