Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065300 | 0.90 | SLC6A2 (0.46) | SIGMAR1CYP1A2CYP2D6OPRK1TP53 | |
| SCHEMBL4055092 | 0.82 | SIGMAR1 (0.39) | SIGMAR1SLC6A2KMT2ALMNAMAPT | |
| SCHEMBL4056479 | 0.81 | SLC6A2 (0.44) | OPRK1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4937965 | 0.78 | SLC6A2 (0.41) | SLC6A2HTR2CSLC6A4SLC6A3KCNH2 | |
| SCHEMBL4937969 | 0.77 | SLC6A2 (0.40) | OPRK1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4062000 | 0.77 | KDM4E (0.38) | SLC6A2KMT2ASLC6A4SLC6A3KCNH2 | |
| SCHEMBL4944257 | 0.77 | CCKBR (0.36) | CYP1A2CYP2D6OPRK1CYP3A4MEN1 | |
| SCHEMBL4056101 | 0.76 | SLC6A2 (0.42) | SLC6A2KMT2ASMN1; SMN2SLC6A4SLC6A3 | |
| SCHEMBL4055078 | 0.76 | SLC6A2 (0.35) | SLC6A2KMT2ASLC6A4HTR6SLC6A3 | |
| SCHEMBL4059102 | 0.75 | TRPV4 (0.40) | TP53SLC6A2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |