Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059943 | 0.90 | TSHR (0.39) | KIF11SLC26A6SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3871312 | 0.82 | KIF11 (0.46) | KIF11SLC26A6SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4042343 | 0.81 | KIF11 (0.38) | KIF11SLC26A6SMN1; SMN2LMNAPOLB | |
| SCHEMBL4058305 | 0.79 | KIF11 (0.44) | KIF11SLC26A6MAPTALDH1A1LMNA | |
| SCHEMBL4060901 | 0.79 | KIF11 (0.42) | KIF11SLC26A6MAPTALDH1A1LMNA | |
| SCHEMBL4037716 | 0.77 | KIF11 (0.68) | KIF11 | |
| SCHEMBL4061532 | 0.75 | KIF11 (0.41) | KIF11MAPTALDH1A1LMNAHPGD | |
| SCHEMBL4059248 | 0.74 | SLC26A6 (0.43) | KIF11SLC26A6SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5233038 | 0.73 | SLC26A6 (0.39) | KIF11SLC26A6SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3869131 | 0.73 | KIF11 (0.52) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-B1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |