Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | ITK | Q08881 | 4/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | ATP4A | P20648 | 1/20 | 0.43 |
| ▸ | ATP4B | P51164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28780911 | 0.82 | CYP1A1 (0.52) | CYP1A1RETITKSYKMAPT | |
| SCHEMBL1901060 | 0.80 | GSK3B (0.56) | RETITKKDR | |
| SCHEMBL4255143 | 0.77 | CLK2 (0.47) | RETSYKMAPTDAOKDR | |
| SCHEMBL15941853 | 0.74 | CYP1A1 (0.52) | CYP1A1RETITKSYKMAPT | |
| SCHEMBL4006784 | 0.72 | METAP2 (0.56) | — | |
| SCHEMBL593538 | 0.71 | FGFR1 (0.80) | PDPK1FGFR1KDR | |
| SCHEMBL28704770 | 0.70 | ATP4A (0.46) | CYP1A1RETITKSYKMAPT | |
| SCHEMBL17674149 | 0.70 | MAPT (0.56) | CYP1A1ITKSYKMAPTTRPA1 | |
| SCHEMBL17674070 | 0.70 | MAPT (0.46) | CYP1A1RETITKSYKMAPT | |
| SCHEMBL30869753 | 0.70 | CYP1A1 (0.68) | CYP1A1MAPTKDM4EPDPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (publ) (SE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147874-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2007-12-27 | — | — | WO | claimed |