Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.48 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060564 | 0.88 | KIF11 (0.46) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL4037033 | 0.88 | KIF11 (0.49) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL3865058 | 0.88 | KIF11 (0.59) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL4057334 | 0.84 | KIF11 (0.46) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL4066139 | 0.82 | MAPT (0.43) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL4058305 | 0.80 | KIF11 (0.44) | KIF11MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL5316296 | 0.79 | MAPT (0.40) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL4060770 | 0.79 | MAPT (0.46) | KIF11KIF23MAPTKDM4EALDH1A1 | |
| SCHEMBL3875938 | 0.78 | KIF11 (0.83) | KIF11KIF23 | |
| SCHEMBL3867342 | 0.78 | KIF11 (0.83) | KIF11KIF23 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-B1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |