Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 3/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066139 | 0.90 | MAPT (0.43) | MAPTKIF11KIF23RXFP1THRB | |
| SCHEMBL5233894 | 0.88 | KIF11 (0.47) | MAPTKIF11KIF23ALDH1A1HPGD | |
| SCHEMBL4060770 | 0.83 | MAPT (0.46) | MAPTKIF11KIF23RXFP1THRB | |
| SCHEMBL5237790 | 0.81 | SLC26A6 (0.41) | MAPTKIF11RXFP1THRBALDH1A1 | |
| SCHEMBL4060564 | 0.81 | KIF11 (0.46) | MAPTKIF11KIF23RXFP1THRB | |
| SCHEMBL4066692 | 0.79 | KIF11 (0.48) | MAPTKIF11KIF23RXFP1THRB | |
| SCHEMBL4057334 | 0.79 | KIF11 (0.46) | MAPTKIF11KIF23RXFP1THRB | |
| SCHEMBL5316070 | 0.78 | KIF11 (0.47) | MAPTKIF11KIF23ALDH1A1HPGD | |
| SCHEMBL5232886 | 0.78 | KIF11 (0.51) | MAPTKIF11KIF23HPGDKDM4E | |
| SCHEMBL4037664 | 0.78 | TP53 (0.41) | KIF11KIF23RXFP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018627-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |