Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687962 | 0.91 | RAB9A (0.46) | RAB9ALIPENR1H4JAK2JAK1 | |
| SCHEMBL5262093 | 0.87 | RAB9A (0.49) | RAB9ALIPEDGAT2JAK2JAK1 | |
| SCHEMBL4687840 | 0.87 | RAB9A (0.49) | RAB9ALIPEDGAT2JAK2JAK1 | |
| SCHEMBL8550495 | 0.86 | RAB9A (0.46) | RAB9ALIPENR1H4NPC1DGAT2 | |
| Bromide SCHEMBL8554846 | 0.85 | RAB9A (0.47) | RAB9ANR1H4DGAT2JAK2JAK1 | |
| SCHEMBL5629746 | 0.84 | EPHX2 (0.49) | RAB9ALIPEEPHX2NR1H4GRM3 | |
| SCHEMBL1692721 | 0.84 | RAB9A (0.43) | RAB9APOLBJAK2JAK1MEN1 | |
| SCHEMBL8554848 | 0.82 | RAB9A (0.45) | RAB9ADGAT2JAK2JAK1MEN1 | |
| SCHEMBL8625146 | 0.82 | RAB9A (0.45) | RAB9ANPC1POLBSMN1; SMN2DGAT2 | |
| SCHEMBL24131317 | 0.82 | RAB9A (0.52) | RAB9ALIPEPOLBSMN1; SMN2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008121685-A1 | METHODS OF USE FOR INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |
| EP-1948188-A2 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2008063853-A2 | CANCER TREATMENT METHOD | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007058850-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |