Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554848 | 0.88 | RAB9A (0.45) | RAB9ADGAT2JAK2JAK1MEN1 | |
| SCHEMBL4066696 | 0.86 | RAB9A (0.50) | RAB9ADGAT2JAK2JAK1MEN1 | |
| SCHEMBL9218294 | 0.86 | THRB (0.46) | HTTTSHRALDH1A1GAA | |
| Bromide SCHEMBL8554846 | 0.85 | RAB9A (0.47) | RAB9ADGAT2JAK2JAK1MEN1 | |
| SCHEMBL4594562 | 0.83 | RAB9A (0.43) | RAB9AJAK2JAK1MEN1HPGD | |
| SCHEMBL4687840 | 0.82 | RAB9A (0.49) | RAB9ADGAT2JAK2JAK1MEN1 | |
| SCHEMBL5262093 | 0.82 | RAB9A (0.49) | RAB9ADGAT2JAK2JAK1MEN1 | |
| SCHEMBL8800263 | 0.82 | POLB (0.46) | MEN1KMT2ANPC1NR2F2ALDH1A1 | |
| SCHEMBL8800068 | 0.82 | POLB (0.46) | MEN1KMT2ANPC1NR2F2ALDH1A1 | |
| SCHEMBL8800555 | 0.82 | POLB (0.46) | MEN1KMT2ANPC1NR2F2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871442-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997025041-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |