Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067155 | 1.00 | TTBK1 (0.49) | TTBK1GRIN2BCYP2D6KITAKT2 | |
| SCHEMBL4065715 | 0.84 | TRPA1 (0.51) | TTBK1GRIN2BCYP2D6AKT2JAK2 | |
| SCHEMBL4065710 | 0.84 | TRPA1 (0.51) | TTBK1GRIN2BCYP2D6AKT2JAK2 | |
| SCHEMBL4070985 | 0.81 | TTBK1 (0.52) | TTBK1CYP2D6KITAKT2JAK2 | |
| SCHEMBL4070983 | 0.81 | TTBK1 (0.52) | TTBK1CYP2D6KITAKT2JAK2 | |
| SCHEMBL4067267 | 0.81 | JAK2 (0.53) | TTBK1JAK2JAK3TTBK2 | |
| SCHEMBL4067270 | 0.81 | JAK2 (0.53) | TTBK1JAK2JAK3TTBK2 | |
| SCHEMBL3349140 | 0.70 | PIK3CD (0.43) | AHRPTGS1NQO2 | |
| SCHEMBL3349147 | 0.70 | PIK3CD (0.43) | AHRPTGS1NQO2 | |
| SCHEMBL22931544 | 0.69 | AHR (0.68) | AHRPTGS1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140171454-A1 | Substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Protein Kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-19 | — | — | US | disclosed |
| US-8633205-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-21 | — | — | US | disclosed |
| CN-101142218-B | Pyrrolopyrimidines useful as inhibitors of protein kinase | VERTEX PHARMA | 2013-02-06 | — | — | CN | disclosed |
| EP-1844050-B1 | PYRROLOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2009-01-14 | — | — | EP | disclosed |
| CN-101142218-A | Pyrrolopyrimidines useful as inhibitors of protein kinase | VERTEX PHARMA (US) | 2008-03-12 | — | — | CN | disclosed |
| EP-1844050-A1 | PYRROLOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | Vertex Pharmaceuticals, Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20070004762-A9 | Pyrrolopyrimidines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-01-04 | — | — | US | disclosed |
| WO-2006096270-A1 | PYRROLOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-09-14 | — | — | WO | disclosed |
| US-20060183761-A1 | Pyrrolopyrimidines useful as inhibitors of protein kinase | LEDEBOER MARK | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004762-A9 | Pyrrolopyrimidines useful as inhibitors of protein kinase | PRKDC, MAP3K20, MAP3K5 | TTBK1 328/4885GRIN2B 3897/4885CYP2D6 2994/4885 |
| US-20140171454-A1 | Substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Protein Kinases | PRKDC, DCK, CDK2 | TTBK1 376/4885GRIN2B 3157/4885CYP2D6 3001/4885 |
| US-20060183761-A1 | Pyrrolopyrimidines useful as inhibitors of protein kinase | PRKDC, MAP3K20, MAP3K5 | TTBK1 328/4885GRIN2B 3897/4885CYP2D6 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.