Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | NQO2 | P16083 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | ALPL | P05186 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070911 | 0.89 | IGF1R (0.41) | SYKIGF1RMAPTCYP1A2HPGD | |
| SCHEMBL30702769 | 0.82 | SYK (0.47) | SYKNQO2MAPK1MAPTPOLB | |
| SCHEMBL29155667 | 0.82 | SYK (0.47) | SYKNQO2MAPK1MAPTPOLB | |
| SCHEMBL14723106 | 0.81 | IGF1R (0.54) | SYKIGF1RCCNA2CDK2CCNA1 | |
| SCHEMBL342752 | 0.79 | IGF1R (0.44) | IGF1RMAPTCYP1A2 | |
| SCHEMBL2205494 | 0.79 | PIK3C3 (0.35) | SYKIGF1R | |
| SCHEMBL12615803 | 0.78 | POLB (0.41) | NQO2MAPK1MAPTPOLBCYP1A2 | |
| SCHEMBL4074688 | 0.75 | NTRK1 (0.46) | IGF1RMAPK1CDK2 | |
| SCHEMBL20943748 | 0.74 | SYK (0.47) | SYKMAPK1 | |
| SCHEMBL25136086 | 0.73 | POLB (0.38) | NQO2MAPK1POLBCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |