Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067356 | 0.89 | SYK (0.43) | IGF1RALPLSYKCYP1A2MAPT | |
| SCHEMBL4066820 | 0.78 | NTRK1 (0.47) | AURKA | |
| SCHEMBL342752 | 0.78 | IGF1R (0.44) | IGF1RCYP1A2MAPT | |
| SCHEMBL2205494 | 0.75 | PIK3C3 (0.35) | IGF1RSYK | |
| SCHEMBL29155667 | 0.73 | SYK (0.47) | L3MBTL1SYKKDM4EHSD17B10MAPT | |
| SCHEMBL30702769 | 0.73 | SYK (0.47) | L3MBTL1SYKKDM4EHSD17B10MAPT | |
| SCHEMBL14723106 | 0.71 | IGF1R (0.54) | IGF1RSYK | |
| SCHEMBL1281530 | 0.71 | ALPL (0.53) | L3MBTL1ALPLKDM4EHSD17B10MAPT | |
| SCHEMBL19487125 | 0.70 | ALDH1A1 (0.49) | L3MBTL1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL3759228 | 0.69 | MEN1 (0.46) | IGF1RL3MBTL1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |