Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.55 |
| ▸ | IKBKB | O14920 | 4/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5794253 | 0.98 | GRM2 (0.53) | GRM2IKBKBCHUKHDAC7BTK | |
| SCHEMBL5616388 | 0.90 | GRM2 (0.48) | GRM2IKBKBCHUKHDAC7BTK | |
| SCHEMBL5616614 | 0.86 | IKBKB (0.51) | GRM2IKBKBCHUKBTKMEN1 | |
| SCHEMBL6500578 | 0.85 | HDAC7 (0.51) | GRM2HDAC7ABCB1NPC1RAB9A | |
| SCHEMBL31541702 | 0.83 | HDAC7 (0.66) | IKBKBCHUKHDAC7NPC1RAB9A | |
| SCHEMBL6514862 | 0.83 | HDAC7 (0.66) | IKBKBCHUKHDAC7NPC1RAB9A | |
| SCHEMBL16741757 | 0.81 | IKBKB (0.51) | GRM2IKBKBCHUKBTKMEN1 | |
| SCHEMBL7249446 | 0.81 | SLC6A3 (0.65) | GRM2IKBKBHDAC7NPC1RAB9A | |
| SCHEMBL27867467 | 0.80 | CNR1 (0.41) | GRM2IKBKBCHUKBTKMEN1 | |
| Hydrochloric Acid SCHEMBL5794611 | 0.79 | P2RX1 (0.47) | IKBKBCHUKBTKMEN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034838-A2 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2009-03-18 | — | — | EP | claimed |
| EP-2032142-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-11 | — | — | EP | claimed |
| WO-2007147103-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-12-21 | — | — | WO | claimed |
| WO-2007147109-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-12-21 | — | — | WO | claimed |
| CN-115304506-B | Preparation method of secondary amide compound by activating primary amide through boron salt catalysis | 中国人民解放军国防科技大学 | 2023-11-14 | — | — | CN | disclosed |
| WO-2006104915-A9 | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LTD (GB) | 2008-01-03 | — | — | WO | disclosed |