Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 1.00 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.55 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406745 | 1.00 | DGAT1 (1.00) | DGAT1SOAT1SOAT2BRAFJAK2 | |
| SCHEMBL10197728 | 1.00 | DGAT1 (1.00) | DGAT1SOAT1SOAT2BRAFJAK2 | |
| SCHEMBL180708 | 0.85 | DGAT1 (0.74) | DGAT1SOAT1SOAT2JAK2SYK | |
| SCHEMBL10197900 | 0.82 | DGAT1 (0.70) | DGAT1SOAT1SOAT2JAK2SYK | |
| SCHEMBL410032 | 0.82 | DGAT1 (0.70) | DGAT1SOAT1SOAT2JAK2SYK | |
| SCHEMBL410033 | 0.82 | DGAT1 (0.70) | DGAT1SOAT1SOAT2JAK2SYK | |
| SCHEMBL16546762 | 0.78 | DGAT1 (0.64) | DGAT1SOAT1SOAT2 | |
| SCHEMBL180787 | 0.78 | DGAT1 (0.64) | DGAT1SOAT1SOAT2 | |
| SCHEMBL13664059 | 0.78 | DGAT1 (0.64) | DGAT1SOAT1SOAT2 | |
| SCHEMBL2741577 | 0.77 | BRAF (0.60) | DGAT1BRAFMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | DGAT1 2/4885SOAT1 18/4885SOAT2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.