Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 4/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraethylene Glycol SCHEMBL14109914 | 0.96 | MEN1 (0.79) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL8002283 | 0.96 | MEN1 (0.79) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL27317940 | 0.93 | TSHR (0.68) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL11143375 | 0.92 | TSHR (0.77) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Alcohol SCHEMBL14895457 | 0.90 | TSHR (0.65) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL7858578 | 0.90 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL1924542 | 0.90 | ALDH1A1 (0.77) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL144040 | 0.89 | TSHR (0.72) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL10423729 | 0.89 | MEN1 (0.79) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL27344317 | 0.89 | TSHR (0.72) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849722-A | Cobalt fill of interconnects in microelectronic circuits | 麦德美乐思公司 | 2018-03-27 | — | — | CN | claimed |
| US-20240199731-A1 | IL-17A BINDING PROTEINS | CRESCENDO BIOLOGICS LIMITED (GB) | 2024-06-20 | — | — | US | disclosed |
| CN-116023946-B | Silicon nitride mask layer etching solution, preparation method, application and etching method | 浙江奥首材料科技有限公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4347681-A1 | RIGID PUR/PIR FOAMS, METHOD OF SYNTHESIS OF A POLYOL FOR PRODUCING RIGID PUR/PIR FOAMS, AND METHOD FOR PRODUCING RIGID PUR/PIR FOAMS | puren GmbH (DE) | 2024-04-10 | — | — | EP | disclosed |
| CN-117247238-A | Nano lamellar porous calcium hydroxide and preparation method and application thereof | 华北电力大学（保定） | 2023-12-19 | — | — | CN | disclosed |
| WO-2023194440-A1 | NOVEL URETHANASES FOR THE ENZYMATIC DEGRADATION OF POLYURETHANES | COVESTRO DEUTSCHLAND AG (DE) | 2023-10-12 | — | — | WO | disclosed |
| EP-4257683-A1 | NOVEL URETHANASES FOR THE ENZYMATIC DECOMPOSITION OF POLYURETHANES | Covestro Deutschland AG (DE) | 2023-10-11 | — | — | EP | disclosed |
| US-11667705-B2 | IL-17A binding proteins | CRESCENDO BIOLOGICS LIMITED (GB) | 2023-06-06 | — | — | US | disclosed |
| CN-116023946-A | Silicon nitride mask layer etching solution, preparation method, application and etching method | 浙江奥首材料科技有限公司 | 2023-04-28 | — | — | CN | disclosed |
| WO-2022253685-A1 | RIGID PUR/PIR FOAMS, METHOD OF SYNTHESIS OF A POLYOL FOR PRODUCING RIGID PUR/PIR FOAMS, AND METHOD FOR PRODUCING RIGID PUR/PIR FOAMS | PUREN GMBH (DE) | 2022-12-08 | — | — | WO | disclosed |
| CN-1317932-A | Herbicidal agents for tolerant or resistant soybean crops | AVENTIES CROPS SCIENCES GMBH (DE) | 2001-10-17 | — | — | CN | disclosed |
| CN-1317933-A | Herbicide composition for tolerant or resistant oilseed rape crops | AVENTIS CROPSCIENCE GMBH (DE) | 2001-10-17 | — | — | CN | disclosed |
| CN-1317934-A | Herbicides for tolerant or resistant cotton cultures | AVENTIES CROPS SCIENCES GMBH (DE) | 2001-10-17 | — | — | CN | disclosed |
| CN-1312682-A | Herbicidal compositions for tolerant or resistant corn crops | AVENTIES CROPS SCIENCES GMBH (DE) | 2001-09-12 | — | — | CN | disclosed |
| CN-1312680-A | Herbicidal compositions containing acylated aminophenylsulfonylureas | AVENTIES CROP SCIENCES GMBH (DE) | 2001-09-12 | — | — | CN | disclosed |
| CN-1312683-A | Herbicides for tolerant or resistant cereal cultures | AVENTIES CORPS SCIENCE GMBH (DE) | 2001-09-12 | — | — | CN | disclosed |
| CN-1280458-A | Surfactant system for liquid aqueous preparations | HOECHST SCHERING AGREVO GMBH (DE) | 2001-01-17 | — | — | CN | disclosed |
| US-5646105-A | Cleaning disinfectant | HENKEL ECOLAB GMBH & CO. (DE) | 1997-07-08 | — | — | US | disclosed |
| EP-0668792-A1 | PRE-TREATMENT OF NATURAL GAS TO BE CONDENSED TO LIQUEFIED NATURAL GAS (LNG) | NORSK HYDRO A/S (NO) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994011090-A1 | PRE-TREATMENT OF NATURAL GAS TO BE CONDENSED TO LIQUEFIED NATURAL GAS (LNG) | NORSK HYDRO A.S (NO) | 1994-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667705-B2 | IL-17A binding proteins | IL17A, ILF2, IL15RA | TSHR 3888/4885MAPK1 3182/4885MEN1 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.