Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.59 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 3/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078751 | 0.94 | MAPK14 (0.65) | MAPK14MAP4K1IDO1TDO2UGCG | |
| SCHEMBL2079054 | 0.93 | MAPK14 (0.51) | MAPK14UGCGALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4072292 | 0.84 | MAPK14 (0.45) | MAPK14IDO1 | |
| SCHEMBL4067939 | 0.78 | MAPK14 (0.60) | MAPK14MAP4K1IDO1TDO2UGCG | |
| SCHEMBL2079261 | 0.77 | MAPK14 (0.65) | MAPK14CYP1A2ATRATRIP | |
| SCHEMBL2079342 | 0.75 | MAPK14 (0.66) | MAPK14UGCGATRATRIP | |
| SCHEMBL2079875 | 0.75 | MAPK14 (0.66) | MAPK14IDO1TDO2UGCGCYP1A2 | |
| SCHEMBL19802148 | 0.74 | APP (0.47) | MAPK14MAP4K1KCNN4RPS6KA2ALDH1A1 | |
| SCHEMBL2080727 | 0.73 | MAPK14 (0.62) | MAPK14ATRATRIP | |
| SCHEMBL2076940 | 0.73 | MAPK14 (0.78) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |