Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | PAK4 | O96013 | 3/20 | 0.56 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071502 | 0.91 | NTRK1 (0.61) | NTRK1PAK4PAK1 | |
| SCHEMBL4069145 | 0.88 | PAK4 (0.69) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL4068978 | 0.86 | PAK4 (0.59) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL786513 | 0.85 | ULK1 (0.65) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL29618398 | 0.85 | ULK1 (0.65) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL20352266 | 0.84 | NTRK1 (0.58) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL20352215 | 0.82 | PAK4 (0.67) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL4070230 | 0.81 | NTRK1 (0.63) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL4073719 | 0.79 | PAK4 (0.48) | NTRK1PAK4PAK1SRCCCNA2 | |
| SCHEMBL30482719 | 0.79 | NTRK1 (0.76) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| CN-1905884-A | Pyrazole derivatives as inhibitors of receptor tyrosyne kinases | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |