Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.69 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.69 |
| ▸ | SRC | P12931 | 2/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.67 |
| ▸ | CDK2 | P24941 | 2/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070230 | 0.91 | NTRK1 (0.63) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL4068008 | 0.88 | NTRK1 (0.61) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL20352215 | 0.88 | PAK4 (0.67) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL29618398 | 0.87 | ULK1 (0.65) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL786513 | 0.87 | ULK1 (0.65) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL20352316 | 0.85 | PAK4 (0.63) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL4068978 | 0.85 | PAK4 (0.59) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL20352253 | 0.85 | SRC (0.64) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL28387351 | 0.85 | PAK4 (0.59) | PAK4PAK1SRCCCNA2CDK2 | |
| SCHEMBL20352228 | 0.82 | SRC (0.60) | PAK4PAK1SRCCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |