SCHEMBL4068015

SCHEMBL4068015

c1ccc(CCCNCc2ccncc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.70
MAOA P21397 1/20 0.60
CHRM2 P08172 1/20 0.58
GAA P10253 1/20 0.58
MAPT P10636 1/20 0.58
BCHE P06276 1/20 0.58
ALDH1A1 P00352 2/20 0.56
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MPO P05164 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21591483 0.93 ALDH1A1 (0.57) SIGMAR1MAOACHRM2BCHEALDH1A1
SCHEMBL28188921 0.89 GAA (0.74) SIGMAR1MAOAGAAMAPTBCHE
SCHEMBL4065566 0.89 SIGMAR1 (0.88) SIGMAR1MAOACHRM2GAAMAPT
SCHEMBL7724204 0.87 SIGMAR1 (0.78) SIGMAR1
SCHEMBL11883482 0.87 SIGMAR1 (0.84) SIGMAR1MAOACHRM2GAAMAPT
Bromide SCHEMBL11691228 0.87 SIGMAR1 (0.84) SIGMAR1MAOACHRM2GAAMAPT
SCHEMBL10416538 0.85 SIGMAR1 (0.62) SIGMAR1MAOACHRM2GAAMAPT
SCHEMBL21591441 0.85 CHRM2 (0.66) SIGMAR1CHRM2ALDH1A1TDP1
SCHEMBL4072845 0.83 CHRM2 (0.73) SIGMAR1CHRM2
SCHEMBL7456529 0.83 CHRM2 (0.61) SIGMAR1CHRM2ALDH1A1MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1415986-B1 SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS BANYU PHARMA CO LTD (JP) 2009-04-08 EP disclosed
US-7205417-B2 Spiro compounds BANYU PHARMACEUTICAL CO., LTD. (JP) 2007-04-17 US disclosed
EP-1200440-A1 QUINUCLIDINE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL DISORDERS Vertex Pharmaceuticals Incorporated (US) 2002-05-02 EP disclosed
EP-1196386-A2 N-SUBSTITUTED GLYCINE DERIVATIVES Vertex Pharmaceuticals Incorporated (US) 2002-04-17 EP disclosed
EP-1196385-A1 BETA-AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISEASES Vertex Pharmaceuticals Incorporated (US) 2002-04-17 EP disclosed
WO-2001002361-A1 BETA-AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISEASES VERTEX PHARMACEUTICALS INCORPORATED (US) 2001-01-11 WO disclosed
WO-2001002363-A2 N-SUBSTITUTED GLYCINE DERIVATIVES VERTEX PHARMACEUTICALS INCORPORATED (US) 2001-01-11 WO disclosed
WO-2001002405-A1 QUINUCLIDINE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL DISORDERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2001-01-11 WO disclosed