Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31749048 | 0.78 | — | — | |
| SCHEMBL31677978 | 0.76 | CYP3A4 (0.42) | KDM4EHTT | |
| SCHEMBL30362827 | 0.76 | CYP3A4 (0.42) | KDM4EHTT | |
| SCHEMBL367743 | 0.76 | CYP3A4 (0.42) | KDM4EHTT | |
| SCHEMBL10495179 | 0.74 | CYP3A4 (0.41) | KDM4EHTT | |
| SCHEMBL30233292 | 0.74 | CLK1 (0.37) | MAPK10CLK1DYRK1ATNFIMPDH2 | |
| SCHEMBL28378859 | 0.73 | EGFR (0.34) | — | |
| SCHEMBL11189722 | 0.72 | MAPT (0.43) | MAPK10CLK1DYRK1ATNFHIPK2 | |
| SCHEMBL30617074 | 0.71 | KDM4A (0.46) | MAPK10CLK1DYRK1ATNFHIPK2 | |
| SCHEMBL30696951 | 0.71 | KDM4C (0.42) | KDM4EHTTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254623-A1 | Aminoalkylthio triazolopyridine or triazoloquinoline derivatives, process for their preparation, medicaments containing them, particularly useful as antalgics | LABORATOIRES UPSA (FR) | 1988-01-27 | — | — | EP | claimed |
| US-20240293391-A1 | ISOQUINOLINE AND PYRIDINE BASED CXCR4 ANTAGONISTS | UNIV LEUVEN KATH (BE) | 2024-09-05 | — | — | US | disclosed |
| EP-4359388-A2 | ISOQUINOLINE AND PYRIDINE BASED CXCR4 ANTAGONISTS | Katholieke Universiteit Leuven (BE) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022269027-A2 | ISOQUINOLINE AND PYRIDINE BASED CXCR4 ANTAGONISTS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2022-12-29 | — | — | WO | disclosed |
| US-7501435-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-03-10 | — | — | US | disclosed |
| EP-2013212-A1 | TRIAZOLOQUINAZOLINONE DERIVATIVES AS INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007127138-A1 | TRIAZOLOQUINAZOLINONE DERIVATIVES AS INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070254879-A1 | Inhibitors of checkpoint kinases | MERCK SHARP & DOHME CORP. | 2007-11-01 | — | — | US | disclosed |
| WO-2002081474-A1 | TRIAZOLOPHTHALAZINE / QUINOLINE / ISOQUINOLINE DERIVATIVES WHICH ARE LIGANDS FOR GABA-A RECEPTORS CONTAINING THE ALPHA 5 SUBTYPE | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-17 | — | — | WO | disclosed |
| US-4886805-A | Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present | Centre D'Activite Et De Recherches Pharmaceutique Industrielle Biologique Medicale (FR) | 1989-12-12 | — | — | US | disclosed |
| US-4886805-A | Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present | Centre D'Activite Et De Recherches Pharmaceutique Industrielle Biologique Medicale (FR) | 1989-12-12 | — | — | US | disclosed |
| US-RE30456-E | ANTIFERTILITY AGENTS, ANTIINFLAMATORY AGENTS AND CENTRAL NERVOUS SYSTEM DEPRESSANTS | GRUPPO LEPETIT S.P.A. (IT) | 1980-12-23 | — | — | US | disclosed |
| US-4075341-A | 2-Substituted phenyl-5-triazols [5,1-a] isoquinoline compounds | GRUPPO LEPETIT S.P.A. (IT) | 1978-02-21 | — | — | US | disclosed |
| US-3895113-A | Antifertility methods employing triazoloisoquinoline derivatives | LEPETIT SPA | 1975-07-15 | — | — | US | disclosed |
| US-3895113-A | Antifertility methods employing triazoloisoquinoline derivatives | LEPETIT SPA | 1975-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254879-A1 | Inhibitors of checkpoint kinases | CHEK1, CHEK2, PLK1 | MAPK10 882/4885CLK1 181/4885DYRK1A 560/4885 |
| US-20240293391-A1 | ISOQUINOLINE AND PYRIDINE BASED CXCR4 ANTAGONISTS | CXCR4, CCR5, CXCR1 | MAPK10 1449/4885CLK1 1790/4885DYRK1A 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.