Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30233570 | 0.79 | ALDH1A1 (0.43) | KDM4EPOLBALDH1A1MAPTLMNA | |
| SCHEMBL4068173 | 0.74 | MAPK10 (0.40) | CLK1DYRK1AIMPDH2CLK2CLK3 | |
| SCHEMBL30884168 | 0.74 | BRD4 (0.42) | CLK1DYRK1AALDH1A1LMNACYP1A2 | |
| SCHEMBL27215992 | 0.70 | MAPK10 (0.40) | CLK1DYRK1ACLK2CLK3CDK5 | |
| SCHEMBL3194830 | 0.69 | MAPK1 (0.37) | KDM4EALDH1A1 | |
| SCHEMBL4238291 | 0.69 | CCNT1 (0.38) | CLK1DYRK1ACLK2CLK3CDK5 | |
| SCHEMBL11189722 | 0.67 | MAPT (0.43) | CLK1DYRK1ACLK2CLK3CDK5 | |
| SCHEMBL25666731 | 0.66 | LMNA (0.47) | CLK1DYRK1AKDM4EHTTTNF | |
| SCHEMBL25461085 | 0.63 | MAPK10 (0.50) | CLK1DYRK1AKDM4EHTTTNF | |
| SCHEMBL16114859 | 0.63 | MAPK10 (0.40) | CLK1DYRK1AKDM4EHTTMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999733-B2 | Diacylglycerol kinase modulating compounds | GILEAD SCIENCES, INC. (US) | 2024-06-04 | — | — | US | disclosed |
| US-20230046340-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046340-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | DGKG, DGKB, DGKK | CLK1 420/4885DYRK1A 1065/4885IMPDH2 2012/4885 |
| US-11999733-B2 | Diacylglycerol kinase modulating compounds | DGKG, DGKB, DGKK | CLK1 614/4885DYRK1A 1410/4885IMPDH2 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.