Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.61 |
| ▸ | NOS1 | P29475 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157520 | 0.95 | CHRM2 (0.71) | CHRM2SIGMAR1NOS1CYP1A2CYP2D6 | |
| SCHEMBL4072845 | 0.93 | CHRM2 (0.73) | CHRM2SIGMAR1NOS1CYP1A2CYP2D6 | |
| SCHEMBL21591441 | 0.92 | CHRM2 (0.66) | CHRM2SIGMAR1NOS1CYP1A2CYP2D6 | |
| SCHEMBL6158945 | 0.90 | SIGMAR1 (0.68) | CHRM2SIGMAR1CYP2A6TDP1L3MBTL1 | |
| SCHEMBL16606319 | 0.88 | CHRM2 (0.68) | CHRM2SIGMAR1NOS1CYP1A2CYP2D6 | |
| SCHEMBL6160313 | 0.87 | SIGMAR1 (0.68) | CHRM2SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL6157737 | 0.87 | SIGMAR1 (0.70) | CHRM2SIGMAR1CYP2A6TDP1L3MBTL1 | |
| SCHEMBL6161198 | 0.87 | SIGMAR1 (0.68) | CHRM2SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL29761159 | 0.86 | CYP1A2 (0.74) | CHRM2CYP1A2CYP2D6TDP1ALDH1A1 | |
| SCHEMBL10417734 | 0.86 | CHRM2 (0.62) | CHRM2SIGMAR1NOS1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| EP-1129070-A4 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1129070-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6228872-B1 | PEPTIDE-PROLYL ISOMERASE AND ROTAMASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2001-05-08 | — | — | US | disclosed |
| WO-2000027811-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |