Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158945 | 0.97 | SIGMAR1 (0.68) | SIGMAR1CHRM2EPHX2CYP2A6TDP1 | |
| SCHEMBL6159311 | 0.95 | SIGMAR1 (0.71) | SIGMAR1CHRM2TDP1L3MBTL1 | |
| SCHEMBL6161198 | 0.93 | SIGMAR1 (0.68) | SIGMAR1CHRM2TDP1L3MBTL1 | |
| SCHEMBL6160313 | 0.93 | SIGMAR1 (0.68) | SIGMAR1CHRM2TDP1L3MBTL1 | |
| SCHEMBL6159259 | 0.92 | SIGMAR1 (0.67) | SIGMAR1CHRM2CYP2A6TDP1L3MBTL1 | |
| SCHEMBL16606319 | 0.91 | CHRM2 (0.68) | SIGMAR1CHRM2CYP2A6TDP1L3MBTL1 | |
| SCHEMBL16606311 | 0.88 | CYP1A2 (0.63) | CHRM2CYP2A6TDP1L3MBTL1 | |
| SCHEMBL4068320 | 0.87 | CHRM2 (0.68) | SIGMAR1CHRM2CYP2A6TDP1L3MBTL1 | |
| SCHEMBL4072845 | 0.87 | CHRM2 (0.73) | SIGMAR1CHRM2EPHX2 | |
| SCHEMBL7724204 | 0.84 | SIGMAR1 (0.78) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129070-A4 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1129070-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6228872-B1 | PEPTIDE-PROLYL ISOMERASE AND ROTAMASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2001-05-08 | — | — | US | disclosed |
| WO-2000027811-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |