Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071889 | 0.82 | NPC1 (0.57) | NPC1RAB9AGAAMAPTALDH1A1 | |
| SCHEMBL3649101 | 0.77 | RXFP1 (0.50) | GRM5NPC1NOS2RAB9AGAA | |
| SCHEMBL4070689 | 0.77 | CDK4 (0.55) | CDK5CDK5R1CCND3CCNKCCNA2 | |
| SCHEMBL10584431 | 0.74 | ALDH1A1 (0.42) | NPC1RAB9AMAPTHTTMEN1 | |
| SCHEMBL4065020 | 0.69 | CCND3 (0.43) | GRM5CDK5CDK5R1CCND3CCNK | |
| SCHEMBL30923288 | 0.69 | JAK3 (0.49) | GRM5CCND3CCNKCCNA2CDK2 | |
| SCHEMBL4065994 | 0.69 | CCNA2 (0.45) | PTK2GRM5CDK5CDK5R1NPC1 | |
| SCHEMBL8516383 | 0.68 | TSHR (0.52) | MAPTMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL16694984 | 0.68 | MAPT (0.43) | GRM5CCNA2CDK2MAPTHTT | |
| SCHEMBL4069536 | 0.67 | CDK4 (0.54) | CCND3CCNKCCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | claimed |