Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407150 | 0.86 | BACE1 (0.46) | BACE1KDM4EEPHX2SCN4AMETAP2 | |
| SCHEMBL2303171 | 0.82 | SCN10A (0.38) | BACE1METAP2PKMKCNH2CDK2 | |
| SCHEMBL407073 | 0.76 | BACE1 (0.46) | BACE1KDM4EPKM | |
| SCHEMBL30876113 | 0.75 | BACE1 (0.50) | BACE1KDM4EEPHX2SCN4AMETAP2 | |
| SCHEMBL20660632 | 0.75 | BACE1 (0.50) | BACE1KDM4EEPHX2SCN4AMETAP2 | |
| SCHEMBL407917 | 0.73 | BACE1 (0.51) | BACE1KDM4EEPHX2SCN4AMETAP2 | |
| SCHEMBL404311 | 0.72 | HTR3A (0.41) | BACE1KDM4EHRH3DYRK1A | |
| SCHEMBL2304767 | 0.72 | CYP1A2 (0.48) | BACE1KDM4E | |
| SCHEMBL16174440 | 0.72 | BACE1 (0.46) | BACE1KDM4EMETAP2DYRK1A | |
| SCHEMBL5683013 | 0.71 | BACE1 (0.59) | BACE1EPHX2SCN4ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389066-B1 | CYCLOPENTADIONE DERIVED HERBICIDES | SYNGENTA LTD (GB) | 2017-07-05 | — | — | EP | claimed |
| US-8895474-B2 | Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds | SYNGENTA LIMITED (GB) | 2014-11-25 | — | — | US | claimed |
| US-11958840-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230114472-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2023-04-13 | — | — | US | disclosed |
| EP-3923935-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| CN-113518618-A | Compounds, compositions and methods | 戴纳立制药公司 | 2021-10-19 | — | — | CN | disclosed |
| US-20210292311-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2021-09-23 | — | — | US | disclosed |
| WO-2020168011-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2020-08-20 | — | — | WO | disclosed |
| EP-2389066-B1 | CYCLOPENTADIONE DERIVED HERBICIDES | SYNGENTA LTD (GB) | 2017-07-05 | — | — | EP | disclosed |
| EP-2393769-B1 | NOVEL HERBICIDES | SYNGENTA LTD (GB) | 2014-12-10 | — | — | EP | disclosed |
| US-8895474-B2 | Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds | SYNGENTA LIMITED (GB) | 2014-11-25 | — | — | US | disclosed |
| US-8680339-B2 | Herbicides | SYNGENTA LIMITED (GB) | 2014-03-25 | — | — | US | disclosed |
| US-20120028800-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120021912-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120021912-A1 | NOVEL HERBICIDES | DDT, CYP4X1, CYP1B1 | BACE1 1901/4885KDM4E 1092/4885EPHX2 154/4885 |
| US-11958840-B2 | Compounds, compositions and methods | EIF4EBP1, EIF4B, EIF4E | BACE1 3789/4885KDM4E 2319/4885EPHX2 1206/4885 |
| US-20230114472-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | EIF4EBP1, EIF4B, EIF4E | BACE1 3789/4885KDM4E 2319/4885EPHX2 1206/4885 |
| US-20210292311-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | EIF4EBP1, EIF4B, EIF4E | BACE1 3789/4885KDM4E 2319/4885EPHX2 1206/4885 |
| US-20120028800-A1 | NOVEL HERBICIDES | DDT, CYP4X1, CYP1B1 | BACE1 1901/4885KDM4E 1092/4885EPHX2 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.