Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065961 | 0.88 | ADRB1 (0.52) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL4069218 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1POLBMAPTALOX15TSHR | |
| SCHEMBL4072207 | 0.79 | ADRB1 (0.50) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL1825806 | 0.79 | ADRB1 (0.65) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL30407939 | 0.79 | ADRB1 (0.65) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL29124749 | 0.78 | CHKA (0.35) | ALDH1A1L3MBTL1POLBMAPTRAB9A | |
| SCHEMBL9655124 | 0.77 | ADRB1 (0.63) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL10893618 | 0.77 | ADRB1 (0.63) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| Hydrochloric Acid SCHEMBL3944269 | 0.75 | ADRB1 (0.61) | ADRB1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL4072648 | 0.75 | ADRB1 (0.61) | ADRB1ALDH1A1KDM4EPLA2G1BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |