Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10893618 | 1.00 | ADRB1 (0.63) | ADRB1KEAP1ALDH1A1L3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL3944269 | 0.98 | ADRB1 (0.61) | ADRB1KEAP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL1825806 | 0.98 | ADRB1 (0.65) | ADRB1KEAP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL30407939 | 0.93 | ADRB1 (0.65) | ADRB1KEAP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL28396664 | 0.87 | ADRB1 (0.71) | ADRB1ALDH1A1KDM4EPLA2G1BRAB9A | |
| Acetamide SCHEMBL27716290 | 0.85 | NPC1 (0.60) | ADRB1KEAP1ALDH1A1L3MBTL1POLB | |
| SCHEMBL27934132 | 0.85 | MAPK1 (0.74) | KEAP1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL2131518 | 0.85 | DRD2 (0.67) | ADRB1ALDH1A1L3MBTL1POLBTSHR | |
| SCHEMBL30751119 | 0.85 | DRD2 (0.67) | ADRB1ALDH1A1L3MBTL1POLBTSHR | |
| Fumaric Acid SCHEMBL27621730 | 0.84 | ALDH1A1 (0.50) | ADRB1ALDH1A1L3MBTL1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017516-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2017-11-23 | — | — | US | disclosed |
| US-9682983-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160046633-A1 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2016-02-18 | — | — | US | disclosed |
| CN-1256333-A | Resin composition for coating paper and coating composition for paper and coated paper thereof | SUMITOMO CHEMICAL CO (JP) | 2000-06-14 | — | — | CN | disclosed |
| EP-0518939-A1 | ANTIARRHYTHMIC AGENTS | BTG INTERNATIONAL LIMITED (GB) | 1992-12-23 | — | — | EP | disclosed |
| WO-1991013865-A1 | ANTIARRHYTHMIC AGENTS | ISIS INNOVATION LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| US-4577025-A | Method of preparing α-aromatic propionic acids and intermediates thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1986-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046633-A1 | BMP INHIBITORS AND METHODS OF USE THEREOF | BMP1, BMPR2, BMP2 | ADRB1 1876/4885KEAP1 2534/4885ALDH1A1 4531/4885 |
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | BMP1, BMPR2, BMP2 | ADRB1 1876/4885KEAP1 2534/4885ALDH1A1 4531/4885 |
| US-10017516-B2 | BMP inhibitors and methods of use thereof | BMP1, BMPR2, BMP2 | ADRB1 1876/4885KEAP1 2534/4885ALDH1A1 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.