Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 4/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15282381 | 0.89 | SRD5A1 (0.64) | SRD5A1SRD5A2HTTS100A4CYP19A1 | |
| SCHEMBL4135475 | 0.88 | CES1 (0.61) | SRD5A1SRD5A2HTTCES1S100A4 | |
| SCHEMBL27931277 | 0.87 | F7 (0.47) | SRD5A1SRD5A2CES1RAB9ANPC1 | |
| SCHEMBL22147102 | 0.84 | MAOB (0.44) | SRD5A1SRD5A2HTTCES1RAB9A | |
| SCHEMBL4036595 | 0.84 | HTT (0.44) | SRD5A1SRD5A2HTTRAB9ANPC1 | |
| SCHEMBL4036590 | 0.84 | HTT (0.44) | SRD5A1SRD5A2HTTRAB9ANPC1 | |
| SCHEMBL4161951 | 0.84 | HTT (0.44) | SRD5A1SRD5A2HTTRAB9ANPC1 | |
| SCHEMBL1921628 | 0.83 | KDM4E (0.59) | SRD5A2RAB9ANPC1S100A4LMNA | |
| SCHEMBL22797610 | 0.81 | CNR1 (0.45) | SRD5A1SRD5A2HTTRAB9ANPC1 | |
| SCHEMBL22799510 | 0.80 | SRD5A1 (0.43) | SRD5A1SRD5A2HTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079736-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008083356-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |