SCHEMBL4068772

SCHEMBL4068772

CC(C)c1cc(-c2ncoc2-c2ccccc2C#N)c(O)cc1O

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 15/20 0.43
HSP90AB1 P08238 11/20 0.36
ESR2 Q92731 1/20 0.34
MAPK14 Q16539 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
ALOX15 P16050 1/20 0.33
CYP2C19 P33261 1/20 0.33
PAX8 Q06710 1/20 0.33
HIF1A Q16665 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
IKBKB O14920 1/20 0.32
HSP90B1 P14625 1/20 0.32
TRAP1 Q12931 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28704100 0.85 HSP90AA1 (0.48) HSP90AA1HSP90AB1MAPK14LMNATP53
SCHEMBL28701252 0.82 HSP90AA1 (0.45) HSP90AA1HSP90AB1MAPK14
SCHEMBL13848422 0.82 HSP90AA1 (0.45) HSP90AA1HSP90AB1MAPK14LMNATP53
SCHEMBL4377799 0.80 HSP90AA1 (0.58) HSP90AA1HSP90AB1MAPK14HSP90B1TRAP1
SCHEMBL4071241 0.80 HSP90AA1 (0.43) HSP90AA1HSP90AB1LMNATP53CYP1A2
SCHEMBL4396093 0.78 HSP90AA1 (0.58) HSP90AA1HSP90AB1MAPK14HSP90B1TRAP1
SCHEMBL28701272 0.77 HSP90AA1 (0.45) HSP90AA1HSP90AB1HSP90B1TRAP1
SCHEMBL4392433 0.76 HSP90AA1 (0.47) HSP90AA1HSP90AB1MAPK14HSP90B1TRAP1
SCHEMBL28934605 0.75 HSP90AA1 (0.45) HSP90AA1HSP90AB1ESR2MAPK14
SCHEMBL28691584 0.75 HSP90AA1 (0.44) HSP90AA1HSP90AB1MAPK14LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009066060-A2 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE TOPOTARGET A/S (DK) 2009-05-28 WO disclosed