Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.45 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18105922 | 0.86 | SLC6A12 (0.39) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL8522673 | 0.83 | APLNR (0.62) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL19830981 | 0.79 | APLNR (0.39) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL15514382 | 0.78 | GRM4 (0.48) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL18105684 | 0.78 | APLNR (0.38) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL18105681 | 0.78 | APLNR (0.38) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL11296019 | 0.75 | EPHX1 (0.39) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| Hydrochloric Acid SCHEMBL17049021 | 0.75 | SLC6A12 (0.41) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL23590185 | 0.74 | APLNR (0.65) | SLC6A12SLC6A11APLNRGRM4CYP2C19 | |
| SCHEMBL8318891 | 0.74 | APLNR (0.65) | SLC6A12SLC6A11APLNRGRM4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038283-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | Alantos Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |