Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065002 | 0.84 | ATM (0.49) | ATML3MBTL1EGLN1ALDH1A1POLB | |
| SCHEMBL4068888 | 0.82 | ADORA2A (0.41) | ATMMMP2MMP9L3MBTL1EGLN1 | |
| SCHEMBL4065341 | 0.81 | MMP2 (0.38) | MMP2MMP9L3MBTL1EGLN1ADAMTS5 | |
| SCHEMBL4059321 | 0.71 | EGLN1 (0.51) | L3MBTL1EGLN1POLBLMNA | |
| SCHEMBL4060321 | 0.70 | MAPK8 (0.49) | EGLN1 | |
| SCHEMBL4063922 | 0.69 | CALCA (0.48) | L3MBTL1EGLN1POLBLMNA | |
| SCHEMBL13813016 | 0.68 | EGLN1 (0.50) | MMP9L3MBTL1EGLN1ALDH1A1POLB | |
| SCHEMBL4059838 | 0.67 | CALCA (0.47) | MMP2MMP9L3MBTL1EGLN1ALDH1A1 | |
| SCHEMBL4062668 | 0.67 | CALCA (0.49) | L3MBTL1EGLN1POLBLMNA | |
| SCHEMBL6498988 | 0.67 | EGLN1 (0.49) | L3MBTL1EGLN1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-B1 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | claimed |