Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071315 | 0.95 | PARP15 (0.43) | ELANEMTNR1AMTNR1BPARP15PARP14 | |
| SCHEMBL4079118 | 0.92 | ALDH1A1 (0.42) | ELANEMTNR1APARP15PARP10TNKS2 | |
| SCHEMBL6226036 | 0.89 | PARP15 (0.42) | ELANEPARP15PARP10TNKS2PARP2 | |
| SCHEMBL4070289 | 0.84 | PARP15 (0.45) | ELANEPARP15PARP10TNKS2PARP2 | |
| SCHEMBL4078619 | 0.84 | TNKS2 (0.47) | TNKS2PARP2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4080433 | 0.80 | TNKS2 (0.49) | TNKS2PARP2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4073647 | 0.74 | MAPT (0.40) | ELANEMTNR1AMTNR1BKDM4EMAPT | |
| SCHEMBL523585 | 0.73 | ALDH1A1 (0.54) | MTNR1AMTNR1BKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4073822 | 0.72 | MAPT (0.40) | ELANEMTNR1AMTNR1BKDM4EMAPT | |
| SCHEMBL9657101 | 0.71 | ELANE (0.42) | ELANEMTNR1AMTNR1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |