Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070068 | 0.92 | ELANE (0.42) | ALDH1A1KDM4EHSD17B10ELANEKMT2A | |
| SCHEMBL6226036 | 0.90 | PARP15 (0.42) | ALDH1A1KDM4EHSD17B10ELANEKMT2A | |
| SCHEMBL4078619 | 0.90 | TNKS2 (0.47) | ALDH1A1KDM4EHSD17B10L3MBTL1TNKS2 | |
| SCHEMBL4071315 | 0.87 | PARP15 (0.43) | ALDH1A1KDM4EHSD17B10ELANEKMT2A | |
| SCHEMBL4070289 | 0.85 | PARP15 (0.45) | ALDH1A1KDM4EHSD17B10ELANEKMT2A | |
| SCHEMBL4080433 | 0.85 | TNKS2 (0.49) | ALDH1A1KDM4EHSD17B10L3MBTL1TNKS2 | |
| SCHEMBL523585 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10GPR84KMT2A | |
| SCHEMBL8142680 | 0.78 | GPR17 (0.50) | ALDH1A1KDM4EHSD17B10GPR84KMT2A | |
| SCHEMBL4078396 | 0.74 | ESR1 (0.40) | ALDH1A1KDM4EELANEKMT2AMAPT | |
| SCHEMBL8133930 | 0.73 | GPR17 (0.50) | ALDH1A1KDM4EHSD17B10GPR84KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |