Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631151 | 0.83 | MAPT (0.51) | RAB9ANPC1SMN1; SMN2MAPTKCNMA1 | |
| SCHEMBL4074923 | 0.83 | MAPT (0.51) | RAB9ANPC1SMN1; SMN2MAPTKCNMA1 | |
| SCHEMBL27896064 | 0.82 | GRM5 (0.64) | RAB9ANPC1MEN1MAPK1KMT2A | |
| SCHEMBL11218564 | 0.80 | KCNMA1 (0.71) | RAB9ANPC1SMN1; SMN2MAPTKCNMA1 | |
| SCHEMBL2699617 | 0.80 | POLB (0.55) | RAB9AMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2700484 | 0.80 | MAPT (0.65) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL331634 | 0.79 | FADS1 (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL13342741 | 0.77 | KDM4E (0.60) | MAPTALDH1A1KDM4EMEN1TSHR | |
| SCHEMBL2700124 | 0.77 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4060753 | 0.77 | GRM8 (0.52) | MAPTGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | MERCK SHARP & DOHME CORP. | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | GRM5, GRIK5, GRM2 | RAB9A 2171/4885NPC1 2051/4885SMN1; SMN2 1372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.