Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.42 |
| ▸ | KIF11 | P52732 | 8/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062105 | 0.77 | KIF11 (0.59) | KCNH2KIF11CHRM1CHRM3CHRM2 | |
| SCHEMBL27607778 | 0.76 | KIF11 (0.47) | KCNH2KIF11 | |
| SCHEMBL4066735 | 0.76 | KIF11 (0.47) | KCNH2KIF11 | |
| SCHEMBL4070705 | 0.73 | KIF11 (0.44) | KCNH2KIF11CHRM1CHRM3CHRM2 | |
| SCHEMBL27607773 | 0.71 | KCNH2 (0.46) | KCNH2KIF11 | |
| SCHEMBL4061574 | 0.71 | KCNH2 (0.46) | KCNH2KIF11 | |
| SCHEMBL4058060 | 0.69 | KIF11 (0.56) | KCNH2KIF11 | |
| SCHEMBL4067160 | 0.68 | KIF11 (0.54) | KCNH2KIF11 | |
| SCHEMBL4058859 | 0.66 | KIF11 (0.87) | KCNH2KIF11 | |
| SCHEMBL4246685 | 0.64 | KIF11 (0.47) | KCNH2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515724-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-10-21 | — | — | EP | claimed |