Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.63 |
| ▸ | GRK6 | P43250 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794656 | 0.85 | NTRK1 (0.70) | NTRK1GRK6 | |
| SCHEMBL23217099 | 0.85 | NTRK1 (0.70) | NTRK1GRK6 | |
| SCHEMBL3338355 | 0.85 | NTRK1 (0.70) | NTRK1GRK6 | |
| SCHEMBL4076751 | 0.84 | NTRK1 (0.66) | NTRK1 | |
| SCHEMBL4069819 | 0.83 | NTRK1 (0.63) | NTRK1 | |
| SCHEMBL4073828 | 0.83 | NTRK1 (0.63) | NTRK1 | |
| SCHEMBL57227 | 0.81 | NTRK1 (0.69) | NTRK1 | |
| SCHEMBL4069073 | 0.81 | NTRK1 (0.72) | NTRK1PAK4 | |
| SCHEMBL57226 | 0.81 | NTRK1 (0.69) | NTRK1 | |
| SCHEMBL4149345 | 0.81 | NTRK1 (0.66) | NTRK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| US-20090005396-A1 | Use of Pyrazolyl-Pyrimidine Derivatives in the Treatment of Pain | ASTRAZENECA AB (SE) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005396-A1 | Use of Pyrazolyl-Pyrimidine Derivatives in the Treatment of Pain | P2RX3, DPYD, TYMP | NTRK1 3656/4885GRK6 3552/4885PAK4 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.