Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068011 | 0.88 | CHRM5 (0.39) | MAOBCHKA | |
| SCHEMBL4072840 | 0.84 | CHRNB2 (0.44) | TSHRLMNAHTTSMN1; SMN2 | |
| SCHEMBL10761110 | 0.81 | ALDH1A1 (0.50) | MAOBTSHRALDH1A1AOC3TAAR1 | |
| SCHEMBL23174610 | 0.76 | MAOB (0.43) | MAOBTSHRALDH1A1CA2AOC3 | |
| SCHEMBL4066623 | 0.76 | ALDH1A1 (0.50) | MAOBTSHRALDH1A1AOC3SIGMAR1 | |
| SCHEMBL4067661 | 0.75 | CHRM2 (0.48) | TSHRALDH1A1PPARGLMNASMN1; SMN2 | |
| SCHEMBL9195863 | 0.74 | CA12 (0.44) | TSHRALDH1A1CA12CA2CA9 | |
| SCHEMBL2727275 | 0.73 | KCNH2 (0.50) | MAOBTSHRALDH1A1AOC3MGLL | |
| SCHEMBL1257194 | 0.72 | CA12 (0.42) | TSHRCA12CA2CA9TAAR1 | |
| SCHEMBL3928290 | 0.72 | CA12 (0.47) | TSHRALDH1A1CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |