Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 19/20 | 0.70 |
| ▸ | CTSS | P25774 | 19/20 | 0.70 |
| ▸ | CTSK | P43235 | 19/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070104 | 0.96 | CTSB (0.65) | CTSBCTSSCTSK | |
| SCHEMBL11889783 | 0.92 | CTSB (0.61) | CTSBCTSSCTSK | |
| SCHEMBL346963 | 0.89 | CTSB (0.75) | CTSBCTSSCTSK | |
| SCHEMBL4069892 | 0.88 | CTSB (0.56) | CTSBCTSSCTSK | |
| SCHEMBL11889776 | 0.88 | CTSB (0.65) | CTSBCTSSCTSK | |
| SCHEMBL346070 | 0.86 | CTSB (0.69) | CTSBCTSSCTSK | |
| SCHEMBL346505 | 0.83 | CTSB (1.00) | CTSBCTSSCTSK | |
| SCHEMBL346361 | 0.82 | CTSB (0.93) | CTSBCTSSCTSK | |
| SCHEMBL347016 | 0.82 | CTSS (0.93) | CTSBCTSSCTSK | |
| SCHEMBL347100 | 0.81 | CTSB (0.65) | CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |