Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528286 | 0.89 | LMNA (0.63) | LMNABCL2MCL1CNR1CNR2 | |
| SCHEMBL4061329 | 0.87 | BCL2 (0.50) | LMNABCL2MCL1HSP90AA1HSP90AB1 | |
| SCHEMBL4069050 | 0.84 | BCL2 (0.67) | LMNABCL2MCL1HSP90AA1HSP90AB1 | |
| SCHEMBL4247963 | 0.82 | LMNA (0.52) | LMNABCL2MCL1HSP90AA1MAPK1 | |
| SCHEMBL4069791 | 0.82 | HPGD (0.60) | LMNABCL2MCL1HSP90AA1HSP90AB1 | |
| SCHEMBL28000168 | 0.81 | HSP90AA1 (0.54) | LMNABCL2MCL1HSP90AA1HSP90AB1 | |
| SCHEMBL11212476 | 0.78 | MAPK1 (0.52) | LMNAHSP90AA1CNR1CNR2MAPK1 | |
| SCHEMBL4057923 | 0.77 | BCL2 (0.50) | BCL2MCL1HSP90AA1HSP90AB1HDAC3 | |
| SCHEMBL4069509 | 0.77 | HSP90AA1 (0.48) | LMNABCL2MCL1HSP90AA1HSP90AB1 | |
| SCHEMBL15214045 | 0.77 | NR4A1 (0.61) | BCL2MCL1MAPK1NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |