Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | BCL2 | P10415 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061329 | 0.84 | BCL2 (0.50) | LMNAHPGDALDH1A1HTTCYP1A2 | |
| SCHEMBL4058136 | 0.83 | CYP3A4 (0.57) | LMNAHPGDALDH1A1MAPK1CYP1A2 | |
| SCHEMBL4070902 | 0.82 | LMNA (0.53) | LMNAMAPK1BCL2MCL1HSP90AA1 | |
| SCHEMBL4069050 | 0.81 | BCL2 (0.67) | LMNAHPGDALDH1A1HTTMAPK1 | |
| SCHEMBL31412220 | 0.80 | ALDH1A1 (0.74) | LMNAHPGDALDH1A1HTTMAPK1 | |
| SCHEMBL4249427 | 0.79 | NPC1 (0.63) | LMNAHPGDALDH1A1HTTMAPK1 | |
| SCHEMBL4069791 | 0.79 | HPGD (0.60) | LMNAHPGDALDH1A1HTTCYP1A2 | |
| SCHEMBL8338080 | 0.79 | HTT (0.56) | LMNAHPGDALDH1A1HTTMAPK1 | |
| SCHEMBL28000168 | 0.79 | HSP90AA1 (0.54) | LMNASLC6A2CYP2C19BCL2MCL1 | |
| SCHEMBL29175710 | 0.78 | NPC1 (0.66) | LMNAHPGDALDH1A1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |