Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903709 | 0.78 | MAPT (0.68) | CNR1CNR2MEN1KMT2ABRAF | |
| SCHEMBL4064115 | 0.78 | GRM8 (0.52) | MEN1KMT2AMAPTGRM8GRM7 | |
| SCHEMBL4060811 | 0.77 | GRM8 (0.56) | MEN1KMT2AMAPTGRM8GRM7 | |
| SCHEMBL4058614 | 0.77 | GRM8 (0.53) | GRM8GRM7GRM4NPSR1HTR2C | |
| SCHEMBL4062656 | 0.77 | PNLIP (0.60) | KMT2AGRM8GRM7GRM4ALDH1A1 | |
| SCHEMBL4061697 | 0.76 | GRM8 (0.55) | GRM8GRM7GRM4NPSR1HTR2C | |
| SCHEMBL4067290 | 0.76 | GRM8 (0.53) | MEN1KMT2AMAPTGRM8GRM7 | |
| SCHEMBL4062244 | 0.76 | PNLIP (0.60) | MEN1KMT2AMAPTGRM8GRM7 | |
| SCHEMBL4065181 | 0.75 | GRM4 (0.57) | MEN1KMT2AGRM8GRM7GRM4 | |
| SCHEMBL4069994 | 0.75 | NPC1 (0.54) | MEN1KMT2ABRAFMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |