Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BM
The experimentally established mechanism targets of Amantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 6/20 | 0.93 |
| ▸ | GRIN2A known ✓ | Q12879 | 6/20 | 0.93 |
| ▸ | GRIN2D known ✓ | O15399 | 5/20 | 0.93 |
| ▸ | GRIN3B known ✓ | O60391 | 5/20 | 0.93 |
| ▸ | GRIN2B known ✓ | Q13224 | 5/20 | 0.93 |
| ▸ | GRIN2C known ✓ | Q14957 | 5/20 | 0.93 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 5/20 | 0.93 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.93 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.93 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.93 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.93 |
| ▸ | TSHR | P16473 | 1/20 | 0.93 |
| ▸ | STAT6 | P42226 | 1/20 | 0.93 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amantadine SCHEMBL20136303 | 1.00 | LMNA (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL28543969 | 0.97 | LMNA (0.93) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL29227879 | 0.97 | LMNA (0.93) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL4098 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL20409394 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL3642447 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL15532073 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL21310017 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL21309814 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM | |
| Amantadine SCHEMBL15672299 | 0.96 | GRIN1 (1.00) | LMNATHRBPMP22POLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12409 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| CN-122036494-A | Synthesis method and application of amantadine-butylphthalide eutectic | 佛山大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122010742-A | Continuous flow synthesis method of amantadine hydrochloride | 沈阳化工研究院有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-121570438-A | Sustained and controlled release preparation process and formula of compound paracetamol and amantadine hydrochloride capsules | 海南亚洲制药股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| WO-2026043843-A1 | TETRAHYDROPYRIMIDINE (THP) IONIZABLE LIPIDS FOR EFFICIENT MRNA DELIVERY | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (US) | 2026-02-26 | — | — | WO | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20250387315-A1 | Dental Varnishes Based On Cationic Polymer Dispersions | IVOCLAR VIVADENT AG (LI) | 2025-12-25 | — | — | US | claimed |
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-12473656-B2 | Gold-copper alloy nanostructure and method for synthesizing the same | CITY UNIVERSITY OF HONG KONG (HK) | 2025-11-18 | — | — | US | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| US-5175002-A | Amantadine hydrochloride syspension with enhanced dissolution characteristics for use in soft gelatin capsules | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-12-29 | — | — | US | claimed |
| US-5157151-A | Salts of 1-adamantamine and formulations thereof | ANGRES ISAAC (US) | 1992-10-20 | — | — | US | claimed |
| EP-0473844-A1 | Medicament containing a combination of AZT and amantadin for the treatment of AIDS | Lange, Werner, Prof. (DE) | 1992-03-11 | — | — | EP | claimed |
| WO-1992000066-A1 | AMANTADINE HYDROCHLORIDE SUSPENSION WITH ENHANCED DISSOLUTION CHARACTERISTICS FOR USE IN SOFT GELATIN CAPSULES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-09 | — | — | WO | claimed |
| EP-0316345-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0316345-A4 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE. | LIPOSOME TECHNOLOGY INC (US) | 1989-05-16 | — | — | EP | claimed |
| WO-1988000824-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1988-02-11 | — | — | WO | claimed |
| EP-0003827-B1 | ANTIDEPRESSANT COMBINATION | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-06-10 | — | — | EP | claimed |
| EP-0003827-A1 | Antidepressant combination | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-09-05 | — | — | EP | claimed |
| US-4148896-A | AMANTADINE AND MOLINDONE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-04-10 | — | — | US | claimed |