Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 7/20 | 0.44 |
| ▸ | CA2 | P00918 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436903 | 0.81 | MAPK1 (0.44) | ALDH1A1KMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL11441588 | 0.81 | CYP1A2 (0.47) | ALDH1A1KMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL28620570 | 0.81 | MAPK1 (0.47) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL12918498 | 0.81 | ALDH1A1 (0.66) | ALDH1A1KMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL23398657 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL23398671 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL528347 | 0.79 | RAB9A (0.69) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL31522193 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL13902297 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL200831 | 0.79 | MAPK1 (0.63) | ALDH1A1KMT2ASMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828159-A1 | STORAGE AND TRANSPORT STABILIZERS FOR POLYMERIZABLE COMPOUNDS | BASF SE (DE) | 2021-06-02 | — | — | EP | disclosed |
| US-10336706-B2 | Crystalline form of Eltrombopag free acid | HETERO RESEARCH FOUNDATION (IN) | 2019-07-02 | — | — | US | disclosed |
| US-20170275255-A1 | CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID | HETERO RESEARCH FOUNDATION (IN) | 2017-09-28 | — | — | US | disclosed |
| EP-3188737-A1 | CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID | Hetero Research Foundation (IN) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016035018-A1 | CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID | HETERO RESEARCH FOUNDATION (IN) | 2016-03-10 | — | — | WO | disclosed |
| US-8372822-B2 | Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof | PLIVA HRVATSKA D.O.O. (HR) | 2013-02-12 | — | — | US | disclosed |
| US-20120238612-A1 | POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF | PLIVA HRVATSKA D.O.O. (HR) | 2012-09-20 | — | — | US | disclosed |
| US-8217021-B2 | Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof | PLIVA HRVATSKA D.O.O. (HR) | 2012-07-10 | — | — | US | disclosed |
| US-8143287-B2 | Thrombopoietin mimetics | STATEGICS, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143287-B2 | Thrombopoietin mimetics | STATEGICS, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-7956048-B2 | Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof | PLIVA HRVATSKA D.O.O. (HR) | 2011-06-07 | — | — | US | disclosed |
| US-20100323965-A1 | Thrombopoietin Mimetics | STATEGICS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100323965-A1 | Thrombopoietin Mimetics | STATEGICS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| WO-2010114943-A1 | POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF | PLIVA HRVATSKA D.O.O. (HR) | 2010-10-07 | — | — | WO | disclosed |
| US-20100256212-A1 | POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF | PLIVA HRVATSKA D.O.O. (HR) | 2010-10-07 | — | — | US | disclosed |
| US-7786159-B2 | Thrombopoietin mimetics | STATEGICS, INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786159-B2 | Thrombopoietin mimetics | STATEGICS, INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-20080139621-A1 | Thrombopoietin Mimetics | STATEGICS, INC. (US) | 2008-06-12 | — | — | US | disclosed |
| US-20080139621-A1 | Thrombopoietin Mimetics | STATEGICS, INC. (US) | 2008-06-12 | — | — | US | disclosed |
| WO-2008070583-A2 | THROMBOPOIETIN MIMETICS | STATEGICS, INC. (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336706-B2 | Crystalline form of Eltrombopag free acid | ACKR3, PLG, GCG | ALDH1A1 4015/4885KMT2A 4148/4885MEN1 780/4885 |
| US-20170275255-A1 | CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID | ACKR3, PLG, GCG | ALDH1A1 4015/4885KMT2A 4148/4885MEN1 780/4885 |
| US-20100256212-A1 | POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF | THPO, MPL, PTGER1 | ALDH1A1 2152/4885KMT2A 3367/4885MEN1 1258/4885 |
| US-20080139621-A1 | Thrombopoietin Mimetics | MPL, THPO, TEK | ALDH1A1 2613/4885KMT2A 2684/4885MEN1 569/4885 |
| US-20100323965-A1 | Thrombopoietin Mimetics | MPL, THPO, TEK | ALDH1A1 2613/4885KMT2A 2684/4885MEN1 569/4885 |
| US-20120238612-A1 | POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF | THPO, MPL, PTGER1 | ALDH1A1 2152/4885KMT2A 3367/4885MEN1 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.